Hydrogen-rich water

Hydrogen-rich water

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Hydrogen-rich water, as its name suggests, is hydrogen-rich water. Japanese is “water and water.” For a long time, biologists have always believed that hydrogen is a physiologically inert gas. In the field of diving medicine, high-pressure hydrogen is used as a breathing medium. It is an advanced diving technology. The world’s largest diving depth record of 700 meters is the use of respiratory hydrogen-oxygen mixture. The way to dive. Recent research strongly suggests that hydrogen is a good antioxidant. The solubility of hydrogen in water and other solutions is relatively low, but oxygen can be combined with hemoglobin, which can be absorbed by the body in large quantities through breathing, while hydrogen and nitrogen cannot be absorbed in large quantities. In the field of radiation chemistry, it has been shown that hydrogen can react directly with hydroxyl radicals in solution.

Exploration history

(Buxton et al. 1988), but this has not been valued by biologists. In the field of diving medicine, the oxyhydrogen gas diving process has the situation of breathing high pressure hydrogen gas with dozens of atmospheres. The amount of gas dissolved in the liquid increases with the partial pressure. Scientists have tried to prove that hydrogen or permitting oxygen is dissolved under high pressure. Down reaction, or react with highly reactive free radicals, but the study did not obtain direct evidence of the existence of the reaction

(Kayar et al. 1994). Therefore, most biologists, especially diving medical scientists, have always believed that hydrogen cannot exhibit reducing properties in living organisms, or that hydrogen does not react with any substance in the living body and is a physiologically inert gas. In the early days, a few people thought that hydrogen had anti-oxidation effect. In 1975, someone published a paper in Science, which proved that continuous breathing of 9 atmospheres of 97.5% hydrogen (2.5% oxygen) for 14 days, high-pressure hydrogen can effectively treat animal skin malignant tumors. It is thought to pass the antioxidant effect (Dole et al. 1975). In 2001, French diving medical scientists proved that breathing 8 atmospheres of high pressure hydrogen can treat inflammatory reactions caused by hepatic parasitic infections. It is proved for the first time that hydrogen has anti-inflammatory effects, and it is proposed that direct reaction of hydrogen with hydroxyl radicals is the basis for the treatment of inflammatory damage ( Gharib et al. 2001). However, the above studies have not attracted widespread attention. The main reason may be that high-pressure hydrogen is difficult to be used as a general clinical treatment.

Medical application

In July 2007, a scholar at the Japan Medical University reported in Nature Medicine that 2% hydrogen in animals can effectively scavenge free radicals and significantly improve cerebral ischemia-reperfusion injury. They use chemical reactions and cytology to prove that hydrogen is used. Dissolved in the liquid can selectively neutralize hydroxyl radicals and nitrite anions, and the latter two are the most important mediators of oxidative damage. Currently, no specific scavenging pathway has been found in vivo. Therefore, the basis of hydrogen therapy for cerebral ischemia-reperfusion injury is selective antioxidant activity (Ohsawa et al. 2007). Japanese scholars’ research has quickly attracted widespread attention (currently cited 18 times) (Katherine et al. 2007; Singhal et al. 2008) and has sparked a wave of research on hydrogen treatment of diseases (currently published 11 related studies in the world) . Subsequently, the team again in an animal model of liver and myocardial ischemia, demonstrating that 2% of hydrogen can treat liver and myocardial ischemia-reperfusion injury (Fukuda et al. 2007; Hayashida et al. 2008). Treatment of stress-induced neurological damage, drug toxicity, chronic oxidative stress damage in human type 2 diabetic patients and mouse genetic defects by drinking saturated hydrogen water (Ohsawa et al. 2008; Kajiyama et al. 2008; Sato et al. 2008) ; Nagata et al. 2008; Nakashima-Kamimura et al. 2009).

The University of Pittsburgh Transplant Center has demonstrated that breathing 2% of hydrogen can treat inflammatory lesions caused by small bowel transplantation (Buchholz et al. 2008), which also protects against intestinal ischemia and post-transplant injury (conference data).

These studies have shown that hydrogen, as a selective antioxidant, has a therapeutic effect on many diseases and has a wide application prospect, completely overturning the traditional view that hydrogen is a physiological inert gas. And suggest that hydrogen may be a new bioactive molecule.

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